Two outs later, Billy Hamilton walked and Jose Peraza hit a two-run single. Joey Votto then connected on his 32nd home run to open a 7-0 lead. Adam Duvall reached on a fielding error by third baseman Kris Bryant and Eugenio Suarez drove him home with a double.
Cubs athletic trainer Ed Halbur then came out to the mound, and Lester was pulled. He threw 40 pitches to 11 batters in the second.
It's the second shortest outing of the season for the left-hander, who lasted two-thirds of an inning on July 9 against the Pirates.