"We've done better against [Chacin] more recently, but it's a different animal [Monday]," Cubs manager Joe Maddon said Sunday. "Everyone is going to have this heightened awareness.
"We need a good start out of Q. That's going to be important for us to be successful for us tomorrow. That's a big part of it."
Quintana is 6-2 with a 1.60 ERA against the Brewers in 10 starts, including a 2.17 ERA in six starts this year.
Meanwhile, Chacin has been equally good, sporting a 1.59 ERA in four starts against the Cubs in 2018.