As things stand right now,
CF Albert Almora Jr (Cubs 2012 1st round draft pick), RHSP Duane Underwood Jr (Cubs 2012 2nd round draft pick), RHRP Armando Rivero (ex-Serie Nacional closer who received a $3M+ bonus iwhen he signed with the Cubs in 2013) , LHSP Rob Zastryzny (Cubs 2013 2nd round draft pick), and switch-hitting C-1B-3B Victor Caratini (a Braves Top 10 Prospect acquired by the Cubs in a 2014 trade deadline deal for LHRP James Russell and IF-OF Emilio Bonifacio) are probably the five most-noteworthy Cubs minor leaguers who will be first-time eligible for the Rule 5 Draft post-2016, but (as with Willson Contreras and Jeimer Candelariio in 2015), others (perhaps OF Jake Hannemann, RHSP Tyler Skulina, and/or RHSP Paul Blackburn) could enter the picture during the course of the 2016 season.