The rookie struck out in the first inning and was batting .278. He has played every game since he was called up from Triple-A Iowa on April 17, and he was 3-for-10 in his last three games.
Bryant has thrived at Wrigley Field, batting .327 coming into Thursday's game.
The Cubs began the game short-handed because shortstop Starlin Castro was at a Chicago hospital for the birth of his second child. Addison Russell started at shortstop and Jonathan Herrera was at second, but Herrera moved to third when Bryant was pulled.