The Blackhawks fell 2-1 to the Golden Knights in Game 3 despite a late push Saturday in Edmonton.
Chicago now finds itself on the brink of elimination with Game 4 looming Sunday. Teams with a 3-0 lead are 190-4 (97.9 percent) winning a best-of-seven playoff series.
As in Game 2, the Blackhawks and Golden Knights started out Game 3 with a list of absences and changes. Vegas was without forwards Paul Stastny and Tomas Nosek, both of whom scored in Game 2, and substituted Marc-Andre Fleury for Robin Lehner in net.