Wolves' boss Paul Lambert could recall Andreas Weimann, who scored the winner at Anfield in the fourth round.
Centre back Kortney Hause and midfielder Conor Coady, who both featured in that upset, could return.
Chelsea defender David Luiz is likely to be rested as he continues to struggle with a knee problem, with Kurt Zouma ready to deputise.
Cesc Fabregas and Asmir Begovic are set to start, while Michel Batshuayi and Ruben Loftus-Cheek could feature.
MOTD COMMENTATOR'S NOTES
Steve Wilson: "I'm not sure if Antonio Conte has been versed in just how special the double of league and FA Cup is in England - but this season is a wonderful opportunity for Chelsea to join Manchester United and Arsenal as the only clubs to have achieved it more than once.