Ange Postecoglou revealed that James Maddison's injury will keep him out until the end of the year at least, with Micky van de Ven also out until 2024.
Tottenham travel to Wolves for the Saturday lunchtime kick-off on the back of Monday's 4-1 home defeat to Chelsea, and a raft of injuries and suspensions will mean a much-changed outlook for Postecoglou's Spurs at Molineux.
Earlier on Friday, Postecoglou claimed the Premier League's Manager of the Month award for Spurs' progress in October, his third accolade in three months - but it is not a time for the Australian boss to savour, with a lot of injuries to deal with.