Striker Romelu Lukaku will not feature when holders Chelsea look to overturn a 3-1 deficit against Real Madrid in the Champions League quarter-final.
A substitute in the first leg, Lukaku has not recovered from the Achilles injury that kept him out of Saturday's 6-0 Premier League win at Southampton.
Captain Cesar Azpilicueta has travelled to Spain after missing the Southampton game following a positive Covid test.
Midfielder Ross Barkley misses out with illness.
Callum Hudson-Odoi and Ben Chilwell are still absent with back and knee injuries respectively.
The winners will face Manchester City or Atletico Madrid in the semi-final, with City leading 1-0 before Wednesday's second leg in Spain.