Liverpool welcome to Anfield a Southampton side who are running the real risk of being dragged into the dogfight at the bottom of the table
Victory for Jurgen Klopp's men would place them second in the table, a point behind Chelsea ahead of the Blues facing Manchester United on Sunday.
The Reds enter the match off the back of a 4-0 demolition of Arsenal and European success over Porto, while Southampton arrive having recently suffered a surprise defeat to basement boys Norwich.
Follow Sportsmail's WILL GRIFFEE for live Premier League coverage of Liverpool vs Southampton, including build-up, team news and updates.