Midfielder Carney Chukwuemeka has joined Chelsea's long injury list after requiring knee surgery for an injury he suffered last weekend.
Mykhailo Mudryk also misses out after picking up a minor injury in training while Romeo Lavia is not yet match-fit.
Luton should be well rested after their match last week was postponed due to ongoing work at Kenilworth Road, and have added to their squad by signing goalkeeper Tim Krul.
Defenders Gabe Osho and Dan Potts remain sidelined.
New signing and ex-Chelsea midfielder Ross Barkley is short of match fitness so might not feature.
MATCH FACTS
Head-to-head
- Chelsea have won the past three meetings with Luton in all competitions, with all of these games coming in the FA Cup between 1994 and 2022.