Chelsea head coach Frank Lampard must decide whether to hand Olivier Giroud his first Premier League start of the season following the Frenchman's four-goal haul against Sevilla on Wednesday.
The Blues will recall a number of key players who were rested in midweek.
Diego Llorente is fit for Leeds but boss Marcelo Bielsa says he would prefer the centre-back to play for the under-23 side before making his debut.
Pablo Hernandez, Jamie Shackleton and Adam Forshaw remain sidelined.
LAWRO'S PREDICTION
Whenever I see this fixture I think about the tempestuous 1970 FA Cup final between the teams, which I went to.