Chelsea head coach Antonio Conte must decide whether to recall winger Pedro, who lost his place to Willian for Tuesday's draw at Liverpool.
Conte also has the option of selecting ex-Arsenal midfielder Cesc Fabregas if he opts for a more attacking line-up.
Arsenal hope Olivier Giroud and Alex Oxlade-Chamberlain will pass fitness tests, while Danny Welbeck may return after being rested in midweek.
Aaron Ramsey is likely to be out for three weeks with a calf injury.
Mohamed Elneny is still at the Africa Cup of Nations, while fellow midfielder Granit Xhaka remains suspended.
MOTD COMMENTATOR'S NOTES
Jonathan Pearce: "A Chelsea win will end Arsenal's title challenge.