Arsenal manager Mikel Arteta said ahead of the defeat by Manchester City that William Saliba was unlikely to return from a back injury against Chelsea.
Mohamed Elneny and Takehiro Tomiyasu remain out with knee problems.
Chelsea's Kai Havertz, who has also been nursing a knee issue, could be available on Tuesday.
Kalidou Koulibaly's hamstring injury will be assessed, while Marc Cucurella, Reece James, Mason Mount and Armando Broja are all sidelined.
CHRIS SUTTON'S PREDICTION
Frank Lampard took the job with the best intentions but his spell as interim Chelsea boss has been a disaster, with five defeats out of five.