Arsenal forward Pierre-Emerick Aubameyang may return after recovering from coronavirus but Alexandre Lacazette is yet to resume training following a positive test.
Willian has also returned a positive test and could miss out, while new signing Martin Odegaard has yet to receive visa clearance so can't play.
Romelu Lukaku is set to make his second debut for Chelsea after re-joining the club from Inter Milan.
N'Golo Kante is fit after injury.
LAWRO'S PREDICTION
Mikel Arteta has not taken charge of many Gunners games in front of a full stadium and, the last time he did, he wasn't under the same pressure he is facing now.