Spain have been dealt a triple blow for this month's World Cup qualifiers with key personnel Andres Iniesta, Alvaro Morata and Dani Carvajal all ruled out.
The 2010 winners face host Albania on Friday in Group G before travelling to Israel on Monday as they look to seal qualification for next summer's tournament in Russia.
However, manager Julen Lopetegui will be without Iniesta and Morata due to muscular injuries, while Carvajal has a viral infection related to his heart.
Iniesta was hurt in Barcelona's 3-0 win over Las Palmas on Sunday and is expected to be sidelined for 10 days.