Panthers cornerback Charles Tillman tore the ACL in his right knee in the first half of Sunday's victory against the Tampa Bay Buccaneers and will miss the entire postseason, coach Ron Rivera said.
The Panthers will prepare Robert McClain to replace Tillman as the starter.
McClain has played the last three games since being signed. He had an interception and six tackles on Sunday.
Tillman's injury is to the same knee that caused him to miss four games before he returned to start the past two.
He was brought back a week earlier than hoped after Bene' Benwikere suffered a season-ending fractured leg against Atlanta.