Carolina drafted Silatolu in the second round of the 2012 draft. He played 34 games with 28 starts from 2012-15, battling injuries throughout his tenure. He started a career-high 15 games as a rookie at left guard and later became an option to play tackle if needed.
After his rookie contract expired following the 2015 season, Silatolu signed with Chicago, but the Bears released him before just prior to the 2016 season opener. He did not play in 2016.