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Giants at 49ers: ‘Thursday Night Football’ picks and open thread, powered by Tallysight

Week 3 of Thursday Night Football is a match up that seems good on paper, but may have been better to watch last season. The New York Giants (+10.5)

were a 2022 Cinderella story under first year head coach Brian Daboll. This year, they are rivaling the Carolina Panthers (+6.5) for major injury news. Saquon Barkley is likely out and their offensive line makes ours look like a seasoned unit with years of chemistry built between them. Meanwhile, the San Francisco 49ers (-10.5) are struggling to stop Christian McCaffrey from scoring touchdowns.