Carolina enters this game with the league’s No. 1 rushing offense (166.5 yards per game), and Minnesota enters dead last (47.5 yards per game).
But both teams have been forced to make changes in the backfield.
Running back Jonathan Stewart is out with a hamstring injury, meaning Cameron Artis-Payne, Fozzy Whittaker and Mike Tolbert will combine to carry the load.
"I've got a tremendous amount of faith in who CAP can be for us, and in knowing that you've got a good change-of-pace guy in Fozzy and a guy who can play situational football for you in Mike Tolbert," head coach Ron Rivera said.