CHARLOTTE, N.C. -- Panthers backup quarterback Sam Darnold, who lost the starting job to Baker Mayfield earlier in the week, left Friday's preseason finale against Buffalo on a golf cart after suffering a left ankle injury late in the third quarter.
The team said he would not return.
It was the second time in a week the Panthers lost a quarterback in a preseason game. Third-round pick Matt Corral suffered a season-ending Lisfranc tear in last Friday's preseason loss at New England.
If Darnold's injury is serious the Panthers would be down to two quarterbacks, Mayfield and former XFL star P.