Manchester City forward Ferran Torres will be missing for up to six weeks after suffering a small fracture to his right foot while away with Spain.
Ederson and Gabriel Jesus both began Brazil's World Cup qualifier against Uruguay, which finished in the early hours of Friday morning (BST), and neither is likely to start for City.
Burnley captain Ben Mee is ruled out after testing positive for Covid-19.
Matej Vydra and Charlie Taylor are also doubtful for Saturday's game.
Johann Berg Gudmundsson is fit despite withdrawing from international duty with Iceland, while Maxwel Cornet is back in contention after missing the draw against Norwich because of a hamstring issue.