Liverpool's long-standing rivalry with Manchester United is renewed on Monday, as Jurgen Klopp's side face Jose Mourinho's men at Anfield.
Elsewhere, Everton travel to Manchester City, looking to pick up where Tottenham left off before the international break. Spurs inflicted Pep Guardiola's first defeat as City boss on Oct. 2, and the Catalan will be looking for a response.
At the other end of the table, it's an early relegation scrap, as the league's two winless sides, Stoke and Sunderland, do battle.
Who will come out on top? Predict the winners in each Premier League match by voting in our polls.