With nine games in the Championship and half a dozen in League One, Tuesday could be one of the most significant midweek matchdays this season.
The Championship's top three - Burnley, Sheffield United and Leeds - are all in action. Any one of those teams could finish the night at the summit.
In League One, runaway leaders Birmingham City know a victory will send them up with six matches still remaining.
And it feels like the last-chance saloon for third-placed Wycombe as they play their game in hand on second-placed Wrexham.
Here's what to look out for.