Preston thumped Championship rivals Huddersfield 4-1 in the Carabao Cup at the John Smith's Stadium to pile pressure on manager Danny Schofield.
The Terriers were already in trouble after losing their first two games of the season against Burnley and Birmingham and now they are out of the first domestic cup.
Meanwhile, there was a hammering in an all-League One contest as Exeter thrashed rivals Cheltenham 7-0 to storm into the second round of the Carabao Cup.
The result piles pressure on manager Danny Schofield after his third straight defeat
The Grecians inflicted on Cheltenham their heaviest home defeat for 30 years, while nine Championship clubs crashed out after defeats to lower-league opposition.