Burnley's Charlie Taylor is a doubt with a thigh injury while fellow defender Kevin Long will also be monitored after rolling his ankle.
Jay Rodriguez and Dwight McNeill are also battling injuries and will also be assessed ahead of the game.
Manchester United forward Edinson Cavani is available again after completing a three-match ban.
Victor Lindelof, Luke Shaw and Paul Pogba, who missed the FA Cup weekend win over Watford, are all doubtful.
MATCH FACTS
Head-to-head
- Manchester United have won on their last four Premier League visits to Burnley.