Plymouth have already shocked Brentford and Liverpool in the FA Cup this season, but can they upset another Premier League team, Manchester City, in round five?
"Argyle have gone really direct under new manager Miron Muslic," said BBC Sport football expert Chris Sutton.
"It's a great clash of styles with the possession football that Pep Guardiola plays, but the problem if you keep going long against City is that you keep giving them the ball back."
Sutton has made his predictions for all eight fifth-round ties and for this weekend's matches he is up against comedian and Plymouth fan Josh Widdicombe.