Defense seems to be the Buffalo Sabres biggest weakness going into the 2015-16 season. General Manager Tim Murray has expressed his interest to still add a top four left handed defenseman. At the moment Josh Gorges is the only guy that fits that description and he is known to be injury prone.
Arguably the Sabres best three defenseman in Zach Bogosian, Rasmus Ristolainen, and Mark Pysyk are all right handed. Last season Mark Pysyk played a lot of games on the left side, so at this point I believe he would start on that side with the Sabres.