Offensively, the Jets aren't ready for this game. QB Josh McCown played only three series in the preseason and his two most accomplished receivers, Jermaine Kearse and Jeremy Kerley, arrived only this week. The offensive line, which also didn't get a lot of quality reps, will struggle against Buffalo's front four. The Jets will struggle to score, and their defense will wear down in the fourth quarter after being on the field so long. Bills 24, Jets 13 -- Rich Cimini
There isn't much statistical track record that is relevant in making this projection because the Bills have a first-year coach (Sean McDermott), a new offensive coordinator (Rick Dennison) and a new defensive scheme and secondary.