This is a really interesting matchup. The Buffalo Bills and Carolina Panthers are somewhat mirror images of each other, and of course, this is Sean McDermott's return to Carolina.
McDermott should have a good feel for what Carolina wants to do on offense. He should also be able to help offensive coordinator Rick Dennison prepare to poke holes in the Panthers defense since he knows the personnel so well.
Having said all that, this is still the Panthers and Cam Newton playing at home. Carolina is the more talented team as a whole. The Carolina defense is strong in the front seven and a little weak in the secondary.