and Tennessee Titans (+9.5) will face off on Monday night, and at the risk of overreacting to Week 1 outcomes, these two teams seem to be heading in different directions. The Titans lost to the lowly New York Giants (-3) while the Bills beat the defending Super Bowl champs in their own building.
Be sure to check out all of our coverage for the game.
Three big questions
What is it going to take to stop Derrick Henry?
Henry took one 74 yards to the house against the Bills a year ago as part of a 20-carry, 143-yard performance.