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NFL Week 10 opening odds have Buffalo Bills as road favorites over Indianapolis Colts

Shortly after the Buffalo Bills had defeated the Miami Dolphins and before the paint was dry on promoting the Indianapolis Colts’ game against the Minnesota Vikings in Week 9, opening odds for Bills at Colts in Week 10 became available. While it may seem strange to present odds before both teams play their games, the odds haven’t shifted since last evening.

As such, entering Week 10 the 7-2 Bills are 4.5-point road favorites over the 4-5 Colts with FanDuel Sportsbook. The current moneyline is Bills -250 / Colts +205 (a change from opening moneyline of Bills -220 / Colts +184).