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Giants at 49ers ‘Thursday Night Football’ pick and open thread

This week’s Thursday Night Football matchup between the New York Giants (+10.5)

and the San Francisco 49ers (-10.5) should be an interesting one. DraftKings Sportsbook has the 49ers heavily favored at -10, indicating the expectation that the Niners will dominate the game. The over/under with DraftKings is set at 44.5, suggesting that the total combined score of both teams will likely be around that range.

The San Francisco 49ers have played exceptional football through two weeks, showcasing their offensive and defensive prowess. With running back Christian McCaffrey leading the charge, the 49ers have scored 30 points in each of their first two games.