On FanDuel Sportsbook, the San Francisco 49ers are 1.5-point "home" favorites versus the Buffalo Bills for Monday night's game in Glendale, Arizona, and the total is set at 46.5 points, which implies a 24.00-22.50 win for the Bills.
According to our oddsFire tool, the betting public loves Buffalo in this one. A lopsided 83% of the bets and 75% of the money on the spread is on the Bills to cover, and 90% of the bets on the moneyline are backing Buffalo. Sharp money is all over the under. While 72% of the bets on the total are on the over, just 43% of the money has followed suit, indicating some big bets on the side of the under.