Jan 24, 2021; Kansas City, MO, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) throws a pass against the Buffalo Bills during the fourth quarter in the AFC Championship Game at Arrowhead Stadium. Mandatory Credit: Denny Medley-USA TODAY Sports
The Buffalo Bills will play six opponents in the AFC in 2021. Some of them will be difficult, some of them, not so much.
The Bills have seen some of their AFC opponents as recently as 2020, and as far back as 2018. Outside of their division, the Bills will play the entire AFC South and the other two division winners in the AFC.