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Buffalo Bills vs. San Francisco 49ers second-half open thread

The Buffalo Bills lead the San Francisco 49ers 21-3 at halftime, having put together a dominant winter football clinic through 30 minutes of football. It was an inauspicious start for the Bills, where offensive coordinator Joe Brady appeared caught off guard by the unpredictable weather shift that brought more snow earlier than predicted.

Brady adapted, finding plays that allowed Buffalo’s offensive line to use its strength and power downhill against a 49ers defense unaccustomed to lake-effect snow. San Francisco got the memo about snow-game advantages, and running back Christian McCaffrey was off to a snow-melting start to the evening when suddenly he was off the field and heading to the locker room with an apparent knee injury.