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Welcome back, Buffalo Bills football!
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open their 2022 NFL preseason slate at 4:00 Eastern on Saturday afternoon, when the Indianapolis Colts (-1.5) come to Highmark Stadium.
The Bills have won their last eight preseason games, spanning a stretch of nearly 1,450 days. The last time Buffalo dropped a preseason game was a 28-16 setback to Andy Dalton and the Cincinnati Bengals (-6.