When the Buffalo Bills lost in the 2020 AFC Championship Game, we thought their rematch in the season opener would make a ton of sense. They played both Super Bowl teams in away games the following season, so they were atop the list. Instead, the Tampa Bay Buccaneers hosted the Dallas Cowboys and the returning Dak Prescott in the season opener. The Bills vs. Chiefs became a marquee Sunday night game and the Bills’ game against Tampa ended up in a nationally televised late afternoon time slot.
In 2022, the Bills are once again playing at both Super Bowl entrants and should be at or near the top of the list of matchups the NFL wants to see if either the Cincinnati Bengals or Los Angeles Rams win the big game.