The Bills were coming off a disappointing loss to Miami last week. This week they started what is arguably the toughest stretch of their schedule against the Patriots followed by the Seahawks and Bengals. Coming into this game the Bills were missing a number of players due to injury, including Sammy Watkins, LeSean McCoy and Marquise Goodwin. They did have Marcell Dareus back on defense to help and he played a pretty good game.
Buffalo was able to score first on a 23-yard field goal to take a 3-0 lead.