If Buffalo loses today, or even if they win, the Buffalo Bills (currently 8-7) could potentially be sitting at home thanks to a tiebreaker loss. If it happens, it will be the first time in team history Buffalo loses a tiebreaker for a playoff spot.
If either the Tennessee Titans (8-7) or Los Angeles Chargers (8-7) win their game, Buffalo would lose the tiebreaker to them, even after defeating the Miami Dolphins. The Bills are behind in conference record against the Titans, and lost a head-to-head matchup against the Chargers.
Buffalo has finished one game back of a playoff spot six times in their 58 seasons, most recently in 2014.