(5-3), who entered the 2021 season with legit Super Bowl aspirations, are widely considered to be one of the top teams in the AFC. The same cannot be said of the Jacksonville Jaguars (+10), Buffalo’s opponent last week, but that didn’t stop the Jaguars from pulling off one of the biggest upsets of the season when they defeated the Bills 9-6 in Jacksonville.
It was arguably the worst loss the team has suffered during head coach Sean McDermott’s tenure in Buffalo, a successful span of 4.5 years where the Bills have made the playoffs three times and won nearly 60 percent of their games (43-29 win-loss record).