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Bills vs. Jaguars NFL Week 5 opening odds — Buffalo favored to win ‘at home’ in London

and Jacksonville Jaguars (+4.5) in London has generated significant attention, primarily due to the opening odds on DraftKings Sportsbook heavily favoring the Bills by -4.5 points. Both teams enter this contest on a high note, with Buffalo coming off a dominant victory against the Miami Dolphins (-9.5) and the Jaguars securing an impressive win over the Atlanta Falcons (-2.5) across the pond in Week 4.

As fans gear up for an intriguing clash, let’s analyze the factors that have led to this early line and what we can expect from both teams in this international showdown.