Bills vs. Chargers: Buffalo opens as huge west coast favorites for Week 16

are hitting the road to take on the reeling 5-9 Los Angeles Chargers (+12), and there’s a lot at stake for both teams. The Bills open as 13.5 point favorites, with the over/under set at 42.5. The Moneyline has Buffalo at -950 and the Chargers at +625. But what do all of these lines actually mean?

Let’s break it down. The point spread, in this case 13.5 points, means that the Bills are favored to win by at least that margin. So, if you place a bet on the Bills, they would need to win by 14 points or more for you to win your bet.