Location: New Era Field, Orchard Park, NY
Regular season records: Buffalo (4-2), San Francisco (1-5)
In a nutshell:
The game was a nip and tuck battle through two and a half quarters despite another monster effort by LeSean McCoy, but after Buffalo’s defense forced a turnover on downs at their own 40-yard line late in the third quarter, the Bills outscored the 49ers 21-3 in a span of seven minutes of game clock to win going away 38-16.
For the Bills it was their fourth straight win, marking the first such streak since 2008.