LeSean McCoy is officially doubtful for the upcoming home game against the New England Patriots, making it very likely that he'll miss his first game of the year at a time when the team can least afford to lose him.
McCoy was only questionable when the Bills traveled to Miami to face the Dolphins last week, but his hamstring injury forced him to leave the game after an ineffective three quarters. Mike Gillislee, who is listed as questionable with a foot injury, is expected to play and carry the load. Reggie Bush, he of the garbage time touchdown last week, and Jonathan Williams are available to shoulder some carries as well.