ORCHARD PARK, N.Y. -- Buffalo Bills outside linebacker IK Enemkpali was carted off late in the second quarter of Saturday's preseason opener against the Indianapolis Colts with what coach Rex Ryan called a "major knee injury" during a halftime interview.
Enemkpali's leg bent awkwardly as he was engaged with a blocker while rushing quarterback Scott Tolzien on a second-down incompletion.
The injury potentially further depletes the Bills' depth at outside linebacker. Rookie first-round pick Shaq Lawson underwent shoulder surgery in May that is expected to keep him out until between Weeks 6 and 8, a source told ESPN NFL Insider Adam Schefter, while veteran Manny Lawson remains out with a partially torn pectoral muscle.