The Buffalo Bills (9-2, 7-4 ATS) welcome the San Francisco 49ers (5-6, 4-7 ATS) to Highmark Stadium to finish up a Week 13 Sunday slate with a primetime matchup on Sunday Night Football. The Bills winners of six straight face 49ers team that has struggled so far this season and currently is in fourth place in the NFC West with +600 odds after being the favorite to start the season.
While Buffalo is a 6.5-point favorite fin the matchup, which has heavy amounts of snow in the forecast, the 49ers have won three of their past five games against the Bills.