The Buffalo Bills will play their second straight game against a Super Bowl LVIII combatant, this time hosting the San Francisco 49ers in a game that has major playoff implications for both teams. For the 49ers, a win would draw them back to a .500 record at 6-6, allowing them to keep pace in a weak NFC West division. For the Bills, a win would clinch a franchise-record fifth consecutive AFC East division title.
Mother Nature has some plans for this one, as Lake Effect snow is threatening to wreak havoc on the game.