The Buffalo Bills’ Week 1 game to open the 2024 NFL season doesn’t kick off until we get through the next 111 days on the calendar — nearly a third of a year’s time away in distance. However, it’s not too early to get in on the action with DraftKings, who this past week have shared opening odds for all 32 NFL clubs.
At this juncture, Buffalo sits as seven-point favorites for their season (and home) opener against the Arizona Cardinals. The over/under is currently at 48 points, while the moneyline is at -355 for the Bills, and +255 for the Cardinals.