The Buffalo Bills finished the 2024-25 NFL regular season with a record of 13-4. They finished in first place in the AFC East. The Bills lost to the New England Patriots 23-16 in Week 18.
| Week | Date | Opponent | Location | TV info/Result (ET) |
|---|---|---|---|---|
| Week | Date | Opponent | Location | TV info/Result (ET) |
| 1 | Sun, Sep 8 | vs. Cardinals | Highmark Stadium, Buffalo | Won 34-28 |
| 2 | Thu, Sep 12 | @ Dolphins | Hard Rock Stadium, Miami | Won 31-10 |
| 3 | Mon, Sep 23 | vs. |