Only goal difference separates these two south coast rivals in mid-table, although bragging rights will doubtless be more treasured than swapping ninth for 10th.
Bournemouth will assess Ryan Fraser's hamstring problem, while Harry Arter and Junior Stanislas could return. Tyrone Mings is still suspended.
Manolo Gabbiadini is out with a groin injury and fellow forward Charlie Austin remains sidelined. Defensive talisman Virgil van Dijk is unlikely to play again this season.
That will be a boost to Bournemouth, who have never won at Southampton, losing eight and drawing four of 12 league and cup games on trips along the coast.